Pathogens that have entered the body activate DCs, which leads to migration to the draining lymph node, secondary lymphoid organs, where they trigger a specific tumor-reactive T cell response [26] In vitro DCs are activated to mature by the inflammatory cytokines TNF-α and IL-1, by LPS, and by the CD40 ligand (CD40L) [27]. The gene discussed is CD40LG; the disease is neoplasm.