TLR3 and neoplasm: Similarly, polyinosinic-polycytidylic acid polylysine carboxymethylcellulose (poly-ICLC)—a synthetic Poly(I:C) (TLR3 and MDA5 agonists)—can induce immune response mediated by tumor-specific NK, CTL, and NK-T cells, leading to the robust elicitation of multiple IFNs [40,41].