MMP9 and neoplasm: Figure 2B shows that invasion was significantly reduced in cells treated either with SITO or LS compared to that of the Control group (p < 0.001). The Control group was normalized as 1, and the percentages of invaded cells were 55% and 70% for SITO and LS, compared to 100% of the Control group. Antimigration caused by the SITO treatment was more significant than that of the LS group (p < 0.001). Since MMP-9 plays an important role in tumor cell invasion, we further assayed the expression of this protein with Western blotting (Figure 2C).