SAT1 and neoplasm: Polyamine analogs, such as N1,N11-diethylnorspermine (DENSpm), and N1-ethyl-N11-[(cyclopropyl)methyl]-4,8- diazaundecane (CPENSpm), have provided cytotoxic responses in several tumor types by their ability to upregulate SMOX and Spermidine/spermine N1-acetyltransferase (SSAT) with a consequent increase of H2O2 [9,10].