In a recent study, the treatment of EPCs with exosomes derived from SIRT1-overexpressing adipose-derived stem cells (ADSCs) [55] led to an increased expression of C-X-C motif chemokine 12 (CXCL12) and nuclear factor E2-related factor 2 (Nrf2) in EPCs from acute myocardial infarction patients and, thereby, improved the function of these EPCs. The gene discussed is CXCL12; the disease is acute myocardial infarction.