Seven of the synthesized compounds had the best antiproliferative activities against non-small cell lung carcinoma (A549) and, overall, were more (8r, 8s and 8u) or as active as CA-4 (7u, 7ad, 8q and 8v), with 8u the most active derivative (IC50: 48 nM), showing approximately four-fold improvement over CA-4. The gene discussed is CA4; the disease is non-small cell lung carcinoma.