On the other side, the Gβγ dimer activates numerous signaling pathways involved in the migration of GBM cells, in particular, PI3K, Akt, ERK1/2, mitogen-activated protein kinase (MAPK), and serine/threonine-specific kinases (Raf) pathways [88,89,90]. Here, AKT1 is linked to glioblastoma.