The GBM cells have the ability to adapt their microenvironment by modifying the brain extracellular matrix (ECM), which is a complex mixture of molecules such as glycoproteins—fibronectin, laminins, tenascins (TN) as well as glycosaminoglycans (hyaluronic acid, HA), and proteoglycans that contribute to GBM angiogenesis, invasion, and therapeutic resistance [52]. This evidence concerns the gene ART4 and glioblastoma.