INS and type 1 diabetes mellitus: Metformin in T1D: In the context of metformin used in people with T1D, a recent meta-analysis summarizing eight placebo-controlled trials on the application of metformin in T1D provided evidence of significant weight loss (−2.4 kg; (95% CI −4.2 to −0.65)), a total daily insulin reduction (−1.36 IU; (−2.3 to −0.45)), and improvements in LDL cholesterol in the metformin arm.