These data imply that the mi138-5p regulating GPR124 and inflammasome NLRP3, IL-18, and IL-1β in the decidual endometrium is a possible therapeutic target for improving the rate of embryo implantation in the treatment of infertility, and they provide a new concept regarding the signaling pathway of embryo implantation and decidual programming of human pregnancy. This evidence concerns the gene NLRP3 and Infertility.