In contrast, GRP124 with siRNA invalidated the GRP124-regulated expression of NLRP3, IL-18, and IL-1β in human decidual endometrial stromal cells, indicating that the effects of GRP124 on spontaneous miscarriage are through the expression of inflammasome NLRP3, IL-18, and IL-1β. The gene discussed is IL18; the disease is Miscarriage.