RNase A was found to effectively inhibit motility (Figure 4) and enhance the adhesiveness (Figure S2) of tumor cells as well as block their metastasis (Figure 5); moreover, RNase A significantly affects the expression of key EMT markers not only in B16 melanoma metastatic foci but also in the tissue surrounding them (Figure 6). The gene discussed is RNASE1; the disease is neoplasm.