Our results revealed that the hiPSC-CM line THTC-09 (HLA-A*33:03, HLA-B*58:01, HLA-C*03:02, and HLA-DRB1*03:01) was more susceptible to SAR-CoV-2 infection which correlated with the high level of ACE2 receptor expression. Here, HLA-C is linked to COVID-19.