In fact, a reduction in androgen signaling with five α-reductase inhibitors can reduce ACE2 levels and thereby decrease the internalization of the SARS-CoV-2, suggesting that androgen signaling inhibition can be a potential therapeutic strategy to reduce SARS-CoV-2 viral entry and mitigate severe manifestations in COVID-19 patients [19]. This evidence concerns the gene ACE2 and COVID-19.