CADM2 and obesity due to melanocortin 4 receptor deficiency: The HSD11β1 gene codes for a microsomal enzyme-catalyzing tissue regeneration of active cortisol from the inactive form cortisone. It is highly expressed in metabolic tissues such as the liver and adipose tissue. ↑ plasma cortisol levels have been associated with visceral obesity and metabolic syndrome. An overexpression of this gene has been associated with hyperphagia and obesity in mice.CADM2 plays an important role in systemic energy homeostasis.