CYP3A4 and obesity due to melanocortin 4 receptor deficiency: According to the findings of Menus et al. [61], a moderate/high risk of obesity in patients treated with clozapine was significantly more frequent in low CYP3A4 expressers (13.6% of CYP3A4 low expressers, 1.5% of CYP3A4 normal/high expressers, OR = 13.5 (95% CI 1.2–147.9), n = 87, p = 0.045).