Still, moderate/high risk obesity was significantly more frequent in low CYP3A4 expressers than in normal expressers (13.6% of CYP3A4 low expressers, 1.5% of CYP3A4 normal/high expressers, OR = 13.5 (95% CI 1.2–147.9), p = 0.045). The gene discussed is CYP3A4; the disease is obesity due to melanocortin 4 receptor deficiency.