COMT and metabolic syndrome: When searching for an association of COMT Val158Met (rs4680) variants with MetS, Cote et al. [65] found that atypical AP-treated children with the Met allele had higher systolic (p = 0.014) and diastolic (p = 0.034) blood pressure, and higher fasting glucose concentrations (p = 0.030) compared with children with the Val/Val genotype.