CYP2D6 and schizophrenia: In children treated with atypical APs, Nussbaum et al. [52] found a significant correlation between the CYP2D6 wt/*4 genotype and higher PANSS (Positive And Negative Syndrome Scale, used in schizophrenia) scores, indicating a poor clinical outcome and a bad response to the atypical antipsychotics (p = 0.001).