ASPG and acute lymphoblastic leukemia: Therefore, the present work aims to identify the L-asparaginase gene sequence and produce L-asparaginase from Penicillium sizovae, a filamentous fungus recently reported as an L-asparaginase producer with low glutaminase activity isolated from the soil of the Brazilian Savanna (Cerrado) [41], in recombinant yeast K. phaffii as an alternative to bacterial asparaginases in an attempt to reduce such adverse effects for ALL treatment with greater enzyme yield to meet the market demand.