ASPG and blood coagulation disease: However, adverse effects such as hypersensitivity, coagulation disorders, pancreatitis, hyperglycaemia, hepatotoxicity and resistance to L-asparaginase with antibody formation in children with leukemia and lymphoma as well as in adults undergoing induction treatment for ALL when E. coli and D. chrysanthemi asparaginase were administered have been reported [13].