Another factor that contributes to asparaginase-associated toxic side effects is its L-glutaminase activity, that is, in addition to catalyzing the hydrolysis of L-asparagine, the enzyme also catalyzes the hydrolysis of L-glutamine to L-glutamate and ammonia, which has been implicated in immunosuppression, hepatotoxicity, pancreatitis, and coagulation dysfunction [14]. The gene discussed is ASPG; the disease is pancreatitis.