GSDMD and viral infectious disease: Moreover, disulfiram also covalently targets multiple enzymes, including aldehyde dehydrogenase (ALDH2) [16], dopamine beta hydroxylase (DBH) [26], gasdermin D (GSDMD) [21], pyruvate dehydrogenase kinase 1 (PDK1) [27], ubiquitin E3 ligase breast cancer-associated protein 2 (BCA2) [28], human monoacylglycerol lipase (hMGL) [30], and human cathepsin L. A multi-target pharmacological approach against enzymes that are directly or indirectly associated with SARS-CoV-2 infection may improve the treatment of severe viral infection and reduce the emergence of drug-resistant variants.