Previously, it was shown that several thiuram disulfide or dithiobis-(thioformate) compounds have high potency against Mpro and PLpro of SARS-CoV-2 and human cathepsin L. Yet, we desired to further investigate whether these compounds also inhibited other proteases related to the SARS-CoV-2 infection to provide further benefits in COVID-19 treatment and, most importantly, spare essential human proteases involved in blood clotting. Here, CTSL is linked to COVID-19.