ACE2 and hypertensive disorder: Renin participates in the transformation of angiotensinogen into Ang I, and in subsequent steps, Ang I is converted by ACE into Ang II (which induces vasoconstriction and hypertension via the interaction with angiotensin receptors 1R and 2R (AT1R, AT2R)), while ACE2 converts Ang II to Ang 1–7 exerting vasodilatory effects via the interaction with the Mas receptor.