They first demonstrated the ability of miR-217 to negatively regulate the 3′UTR of SIRT1, causing a decrease in SIRT1 mRNA translation; in the same study, SIRT1 knockdown was strictly connected with mesenchymal-to-epithelial transition (MET) in pancreatic cancer cells [205]. This evidence concerns the gene SIRT1 and familial pancreatic carcinoma.