It was shown that the activity of natural plant enzymes, such as polygalacturonases and β-galactosidases, produced during ripening and causing the solubilization of cell walls and fruit softening, resulted in the pectin preparation with potent antiproliferative activity towards colon cancer cells HCT 116 and HT-29 and high potency for Gal-3 binding. Here, LGALS3 is linked to malignant colon neoplasm.