VEGFA and neoplasm: The vascular endothelial growth factor (VEGF) family was reported to be a core mediator in tumor progression and angiogenesis via interacting with VEGFR-1/2/3, the tyrosine kinase receptors, of which VEGFR-2 contributes mainly to increased vascular permeability, endothelial proliferation, invasion, and migration [27,28,29].