Proteins associated with pigmentation were identified in our targeted-proteomics analysis in melanoma cells, which included Ras-related protein Rab-7L1 (Rab29), L-dopachrome tautomerase (Dct), and 5,6-dihydroxyindole-2-carboxylic acid oxidase (Tyrp1). This evidence concerns the gene TYRP1 and melanoma.