Similarly, IL-8 increased IL-8 expression in serum or CSF of TBI patients is associated with an increased chance for mortality and overall worsened pathological outcomes [78], and may be attributed to the chemoattractant properties of IL-8 that recruit and activate monocytes to the site of injury, increasing the overall inflammatory response after TBI or stroke [76,78]. The gene discussed is CXCL8; the disease is Stroke.