In conclusion, our study reveals that the NLRP3 inflammasome complex is down-regulated in TNBCs compared to the Luminal BC phenotype; MYC gene alterations are an independent prognostic factor for PFS and we highlight, for the first time, that the combination axis of NLRP3+/CCND1+ and PYCARD+/CCND1+ is associated with a poor-clinical outcome of BC patients in the Luminal subtype also. This evidence concerns the gene PYCARD and breast cancer.