MSH2 and colorectal cancer: Moreover, E. faecalis has been described as a bacterium involved in colorectal cancer due to the fact that its metabolic products can damage the DNA of intestinal epithelial cells, which may contribute to the formation of neoplasia, and may even disrupt the expression of genes responsible for repairing DNA damage, e.g., PMS1 (PMS1 Homolog 1, Mismatch Repair System Component), MSH2 (MutS Homolog 2), MSH3 (MutS Homolog 3), MSH6 (MutS Homolog 6), and controlling the cell cycle [22].