In addition to its effects in pancreas, it was found that KO of ZnT8 in mice produces increased adiposity, manifestly through the control of serotonin (5-hydroxytryptamine) synthesis, underlining then a potential role of ZnT8 in control of obesity [177] and metabolic syndrome [332] and the importance of developing therapeutics targeting ZnT8 not only in diabetes. This evidence concerns the gene SLC30A10 and obesity due to melanocortin 4 receptor deficiency.