SLC30A8 and obesity due to melanocortin 4 receptor deficiency: Moreover, ZnT8 depletion targeting has been shown to produce detrimental consequences [327], including, but not limited to, increased sensitivity to a high-fat diet [174], obesity susceptibility [328], impaired glucose tolerance, and increased basal insulin clearance [329], and elevated circulating serotonin (5-hydroxytryptamine) [177].