Flavan-3-ols also exhibit anti-inflammatory effects in human intestinal diseases, influencing cellular signaling pathways associated with oxidative stress, such as nuclear factor kappa B (NF-κB), mitogen-activated protein kinases (MAPK), nuclear factor erythroid 2-related factor 2 (Nrf2), and the signal transducer and activator of transcription 1/3 (STAT1/3) [97]. This evidence concerns the gene STAT1 and intestinal disorder.