Apigenin also causes the apoptosis of hyperactive antigen-presenting cells and T and B cells in lupus, most likely by inhibiting the expression of anti-apoptotic molecules regulated by NF-κB, especially COX-2 and the apoptosis regulator c-FLIP, which are constantly overexpressed by immune cells in lupus [47]. This evidence concerns the gene PTGS2 and systemic lupus erythematosus.