Indeed, though still debated, many previous studies have suggested a positive role of low amount of alcohol, especially wine, on NAFLD [13,14,22,23,24], through beneficial effects on insulin sensitivity, plasma adiponectin and systemic inflammation [10,25,26,27], but a potential protective effect on hepatocellular carcinoma was never convincingly demonstrated. Here, INS is linked to metabolic dysfunction-associated steatotic liver disease.