It has been found that pro-inflammatory cytokines, including resistin, leptin, and TNFα promote the digestion of the extracellular matrix by MMP-2 and MMP-9, leading to the formation of aneurysms, while adiponectin is the only known compound that is secreted by adipose tissue and limits the development of aneurysms. The gene discussed is LEP; the disease is aneurysm.