Compared with the NC group, p-JNK/JNK and p-IRS-1ser307/IRS-1 ratios in hippocampal tissues of the mice from the OC group revealed a significant increase (p < 0.05); in contrast, p-PI3K/PI3K and p-Aktser473/Akt ratios exhibited an obvious decrease (p < 0.05), suggesting that a high-fat diet contributes to inflammation-induced insulin resistance. The gene discussed is MAPK8; the disease is Insulin resistance.