Compared with the NC group, the expression of IL-6 and TNF-α in hippocampal tissues of the mice from the OC group showed a significant increase (p < 0.05); on the contrary, swimming intervention reversed the obesity-induced increase of IL-6 and TNF-α (p < 0.05; p < 0.01) (Figure 4B,C). This evidence concerns the gene TNF and obesity due to melanocortin 4 receptor deficiency.