NR1H4 and metabolic dysfunction-associated steatotic liver disease: Early studies revealed that the active constituents of Alisma orientalis (Sam.) such as Alisol A 24-acetate and Alisol B 23-acetate had anti-NAFLD activity, and the molecular mechanisms might be partly linked with AMPK [23], adiponectin [24], or activation of Farnesoid X receptor (FXR) [25,26,27].