Although the precise mechanisms about how Alisol-B-upregulated RARα expression still need to be further investigated, our study did highlight the important role of RARα on hepatic steatosis, oxidative stress, and inflammation, which generated a novel therapeutic strategy targeting RARα-PPARγ-CD36 cascade for the treatment of NASH. This evidence concerns the gene CD36 and metabolic dysfunction-associated steatohepatitis.