NR1H4 and metabolic dysfunction-associated steatohepatitis: Some studies have implicated the diverse mechanisms of Alisma orientalis extracts against NASH, and Alisol A 24-acetate and Alisol B 23-acetate were reported to ameliorate NASH via stimulating autophagy and regulating AMPK/mTOR signaling [34] or activating FXR [27], respectively.