Important inflammatory factors associated with pyrexia and related symptoms include interleukin-1 (IL-1), IL-6, and tumor necrosis factor (TNF), while pain-related inflammatory factors including prostaglandin E2 (PGE2) and bradykinin (BK), PGE2, and nitric oxide (NO) are all related to inflammation-associated vasodilation. The gene discussed is TNF; the disease is Fever.