FOLR1 and neural tube defect: The identification of folate receptor alpha autoantibodies (FRαAuAb) in women with NTD pregnancy prompted us to re-evaluate folate supplementation during pregnancy to determine if a specific form of folate would be preferable; especially since a significant number of women (60–70%) with a history of NTD pregnancy [16] or autism spectrum disorder (ASD) in the offspring [25] are positive for the FRαAuAb [26,27].