CTSE and pachyonychia congenita: Zhu and coworkers designed an AIE-type activatable probe, QM-HSP-CPP, in which QM serves as an AIE core, HSP offers the specific recognition site of Cathepsin E (CTSE) that is overexpressed in pancreatic cancer (PC), and CPP guarantees the desirable amphiphilic characteristic for ensuring cell/tissue penetrating ability (Figure 3a) [57].