Whole plant extract suppressed LPS-induced NO and PGE2 production, and COX-2 expression in RAW 264.7 cells [320]. Stachyurin (or Casuarinin) reduced ethanol-induced gastric ulceration in rats by increasing mucin production and reducing acidity; it also increased glutathione and catalase levels; it suppressed the immunoexpressing of NF-κB, COX-2, and iNOS to their normal values [207]. The gene discussed is NOS2; the disease is gastric ulcer.