EGFR and non-small cell lung carcinoma: Among rare EGFR mutations, G719X (including G719S, G719A, G719C, and G719D) substitutions in the phosphate-binding “P-loop” within the N-lobe, is one of the most commonly observed mutations, and represent roughly 1.5–3% of all EGFR mutations in NSCLC patients [10] G719X mutations could occur as an independent EGFR one or together with other additional point mutations (rare or classical) as compound EGFR mutations [17].