The targets that are currently being explored for the development of COVID-19 inhibitors include: S protein, ACE-2, TMPRSS2, and furin, as these are involved in the process of virus internalization; and viral proteases such as RdRp, PLpro, and Mpro, as these are involved in virus transcription and replication [146,147,148,149]. The gene discussed is TMPRSS2; the disease is COVID-19.