In LPS treated renal tubular epithelial NRK-52E cells (AKI), emodin also inhibited LPS-induced TLR2, NF-κB, TNFα, IL-1β and IL-6 expression in vitro, which may contribute to the immune regulation of emodin in LPS-induced acute kidney injury [154]. The gene discussed is IL1B; the disease is acute kidney injury.