In the case of hyperlipidemia-induced oxidative stress and inflammation of heart, aloe-emodin significantly reduced the expression levels of proinflammatory cytokines (IL-1β, IL-6, and TNFα), as well as vascular cell adhesion molecule 1 (VCAM1) and intercellular adhesion molecule 1 (ICAM-1). This evidence concerns the gene VCAM1 and hyperlipidemia.