In pancreatic cancer AsPC-1 and MiaPaCa-2 cells, Bao et al. [147] discovered that a CUR analog CDF suppressed the expression of histone methyltransferase EZH2, EpCAM, ABCG2, Shh, MMP-9, cleaved Notch-1, and Hes-1, while increasing the miR expressions of let-7 family miRs, miR-26a, 101, 146a, and 200. The gene discussed is NOTCH1; the disease is familial pancreatic carcinoma.