The results showed that similar to Dex, Renifolin F (3.0 and 1.5 mg/kg) can significantly improve the pathological features of asthma and reduce the occurrence of airway hyperresponsiveness in OVA-induced allergic asthma mice, and the levels of mucin and related inflammatory factors in mice serum and BALF were inhibited. Here, MUC5AC is linked to asthma.