With this aim, we report herein the development of radioiodinated ((S)-[125I]2) and radiofluorinated ((S)-[18F]3) mIDH1 specific tracers for SPECT and PET imaging of low-grade gliomas and CHS, chosen as central as well as peripheral solid tumours most frequently harbouring IDH1 mutations (Figure 2). The gene discussed is IDH1; the disease is central nervous system cancer.