IKBKB and cancer: These findings may suggest that rhodanine derivatives with aminoalkoxy substituents, such as the molecule 53-bearing 4-methylpiperazinylpropoxyphenyl group in the western part and the para-carboxamidophenoxyphenyl moiety in the eastern part of the rhodanine nucleus, could become potential candidates for the treatment of the diseases linked with NF-ĸB activation, such as cancer, as effective IKKβ inhibitors.