The pentose phosphate pathway is a metabolic pathway parallel to glycolysis [52], in which activation of (PPP) enzymes, namely glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD), significantly affects tumor metabolism by contributing to malignant transformation, enlarging tumor progression, preventing cell apoptosis, and promoting tumor metastasis and angiogenesis [53]. The gene discussed is PGD; the disease is neoplasm.