Zhao et al., investigated if administration of 3 g/L caffeine (non-selective antagonist of A2AR) in drinking water or gene knockout (A2AR KO mouse model) can elevate cognitive impairment by reducing Tau-hyperphosphorylation induced by traumatic brain injury (TBI) using a mouse model of moderate cortical impact [60]. The gene discussed is MAPT; the disease is Cognitive impairment.