➢administration of 3 g/L caffeine in drinking water or A2AR KO mouse model can increase cognitive impairment by reducing Tau-hyperphosphorylation induced by TBI mouse model➢cognition was assessed using the Morris water maze test (day 7 and week 4 post-treatment)➢post-mortem (immunohistochemistry, Golgi staining, Western blotting were also performed. Here, MAPT is linked to Cognitive impairment.