subjects with cognitive decline during follow up (MCI > DEM), had significantly lower baseline plasma caffeine concentration than participants who maintained their level of cognitive impairment (stable MCI)a critical baseline plasma concentration of 1200 ng/mL was identifiedout of 11 cytokines measured, 3 (GCSF, IL-10, and IL-6) were lower in participants who experienced cognitive decline from initial MCI to DEM. The gene discussed is IL6; the disease is Cognitive impairment.