The potential mechanism of radiosensitization was achieved by decreasing the ratio of Bcl-2/Bax, inducing apoptosis in glioblastoma cells, and downregulating the expression of HIF-1α, MMP-2, and Wee1 via the HIF-1α/MMP-2 signaling pathway [52]. The gene discussed is MMP2; the disease is glioblastoma.