In the elevated plus-maze test, Liu et al. found that Lonicerae japonicae polysaccharides significantly reduced the time in the open arms as compared to the control group, and there was a negative correlation between the open arm and depression [107], and the expression of NLRP3, IL-1β, and Caspase-1 in the hippocampus of depressed mice was inhibited significantly. The gene discussed is IL1B; the disease is major depressive disorder.