ERBB2 and breast carcinoma: The biological mechanism of the antiangiogenic and antitumor effects of squalamine was also evaluated in vitro with MCF-7 (Michigan Cancer Foundation-7) human breast cancer cell line and in vivo with HER-2 breast tumor xenografts, where squalamine treatment (at 2 mg/kg daily) reduced the growth of tumors as compared to controls (Table 1).