Mechanistically, miRNA200b may protect against senescence and inflammation in MLE cells by downregulating the expression of zinc finger E-box binding homeobox 2 (ZEB2), which is a transcription factor consisting of many functional domains that interact with transcriptional co-effectors implicated in the attenuation of the inflammatory response pathway in pulmonary emphysema [95,96]. This evidence concerns the gene ZEB2 and pulmonary emphysema.