Immune dysregulation in the background of dysregulated pro-inflammatory factors and inflammatory mediators, such as interleukin-2 (IL-2), prostaglandin E2 (PGE2), serotonin, histamine, proteases, and platelet activating factor, has been generally accepted as the main factor contributing to CKD-aP [2,3,7,8,9,10]. The gene discussed is IL2; the disease is chronic kidney disease.