The causes are considered to be: autoimmunity; higher serum levels of proinflammatory cytokines (such as interleukin 23-IL-23) that may affect folliculogenesis [11]; and elevated levels of VEGF (vascular endothelial growth factor), with an increased production of keratinocytes in psoriasis leading to increased superficial cortex vascularization, which causes depletion of ovarian follicles [12]. The gene discussed is VEGFA; the disease is psoriasis.