CX3CL1 and Insulin resistance: We also found that CX3CL1 expression was lower in the epididymal white adipose tissue (eWAT) of HFD-induced obese C57BL/6J mice, and the long-term (4 weeks) in vivo expression of CX3CL1 by pLIVE® vector (plasma CX3CL1 concentration; 220–250 ng/mL vs. 150–170 ng/mL by empty vector) alleviated insulin resistance and inflammation in the liver and eWAT of obese mice [76].