IL1B and ocular melanoma: The occurrence of OM is related to the action of cytostatic medication and radiotherapy by direct mechanisms, through the occurrence of apoptosis, and indirect mechanisms, through which proinflammatory mediators such as tissue necrosis factor, interleukin 1 beta and 6 are released, with the concomitant decrease of other anti-inflammatory cytokines, such as: interleukin 10 or transforming growth factor beta [19].