In multivariate analysis, BUN > 19.8 mg/dL (OR 3.695, 95% CI 1.431–9.540; p = 0.007), lactate > 1.79 mmol/L (OR 3.868, 95% CI 1.228–12.183; p = 0.021), PCT > 2.66 ng/mL (OR 5.455, 95% CI 1.787–16.649; p = 0.003), and PSS > 572 pg/mL (OR 2.508, 95% CI 1.041–6.040; p = 0.040) were identified as independent predictors of AKI development. This evidence concerns the gene CALCA and acute kidney injury.